Find the sum or difference.

$43+\left(-22\right)$

To add two numbers with similar signs, add their absolute values and keep the similar sign with the resulting number.

To add two numbers with opposite signs, subtract the absolute value of smaller number from absolute value of larger number and keep the sign of larger number with the resulting number.

The difference of the numbers $7-3=4$ is positive because the larger number is positive as well.

And the difference of the numbers $3-7=-4$ is negative because the larger number is negative as well.

To evaluate the sum$43+\left(-22\right)$,observe that both the numbers have opposite sign. So, the numbers will subtract and the resulting number will carry the sign of larger number, that is, positive.

So, the sum is

$\begin{array}{c}43+(-22)=43-22\\ =21\end{array}$

Thus, the sum of the given numbers is$21$.