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Chapter 6: Problem 3

Describe the role of norepinephrine, serotonin, and the repression-related brain circuit in unipolar depression. pp. \(178-180\)

Short Answer

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In unipolar depression, norepinephrine and serotonin (neurotransmitters playing key roles in mood regulation and various other functions) are often found in lower levels. Moreover, overactivity in the repression-related brain circuit, involving areas such as the prefrontal cortex and the amygdala, can lead to increased negative emotions and stress regulation difficulties associated with this condition.

Step by step solution

01

Role of Norepinephrine

Firstly, discuss the role of norepinephrine in the context of unipolar depression. Norepinephrine, a neurotransmitter, plays a crucial role in regulating mood and behaviour. It is often found in lower quantities in the brains of those suffering from unipolar depression.
02

Role of Serotonin

Next, discuss the role of serotonin. Serotonin is another neurotransmitter which regulates mood, appetite, and sleep, among other things. Low levels of serotonin in the brain can cause or exacerbate feelings of depression. Similarly to norepinephrine, low levels of serotonin are also often found in unipolar depression sufferers.
03

Unipolar Depression and the Repression-related Brain Circuit

Lastly, discuss the repression-related brain circuit's role in unipolar depression. This includes areas of the brain such as the prefrontal cortex, hippocampus, amygdala and the thalamus, all of which have been found to show abnormal activity in people with depression. Unipolar depression has been linked to overactivity in this circuit, particularly in the amygdala and prefrontal cortex, leading to increased negative emotions and difficulties in regulating stress.

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